Anxiolytic Effect of Ocimum basilicum Extract in Rats Tested by Elevated Plus-Maze Task
نویسندگان
چکیده
Background: There are reports in traditional medicine about the effectiveness of Ocimum basilicum (OB) in the treatment of anxiety. The Elevated Plus-Maze (EPM) has been predominantly used to investigate anxiety levels in rodents. Objectives: The purpose of the present study was to investigate the effectiveness of extract of OB on rat behavior in the EPM test. Materials and Methods: Male Wistar rats weighing 220 250 g were used in the present study. Forty rats were divided into 4 groups: three OB groups (25, 50, 100 mg/kg oral administration of OB for 7 days) and a saline control group. One day after the last day of feeding, the animals’ behavior in EPM was videotaped for 10 minutes. Then, their behavior scored for formal indexes of anxiety, such as the total distance covered by animals, the percentage of entries into and the time spent in open and closed arms. Results: The results showed that after oral feeding of OB, the percentage of open arms entry and open arms time in EPM increased in the experimental groups. OB extract has no effect on the total distance covered by animals and number of closed arm entries. Conclusions: Our results demonstrated that the extract of OB could induce anxiolytic effect in rats after 1 week oral administration. The effect of OB was not induced through changes in motor activity. Further investigations are necessary for pharmacological providing of OB and better understanding of its anxiolytic properties and neurobiological mechanisms.
منابع مشابه
Anxiolytic Activity of Ocimum Sanctum Leaf Extract
The anxiolytic activity of Ocimum sanctum leaf extract was studied in mice. O.sanctum leaf extract produced significant anxiolytic activity in plus - maze and open field behaviour test models. The effect was compared with diazepam, a standard antianxiety drug.
متن کاملPharmacological Effects of Origanum Vulgare L. in the Elevated Plus-Maze and Open Field Tests in the Rat
Background and Objective: The medicinal plant Origanum vulgare. subsp. vulgare in the Lamiaceae family has been widely used by Iranian people for the treatment of respiratory, gastrointestinal and neurologic disorders. The present study was carried out to evaluate possible anxiolytic effects of aqueous extract of O. vulgare leaves and the flowering branches in rats.Materials and Methods: Anxiol...
متن کاملEvaluation of anxiolytic and sedative effect of essential oil and hydroalcoholic extract of Ocimum basilicum L. and chemical composition of its essential oil
Ocimum basilicum belongs to Lamiaceae family and has been used for the treatment of wide range of diseases in traditional medicine in Iranian folk medicine. Due to the progressive need to anti-anxiety medications and because of the similarity between O. basilicum and Salvia officinalis, which has anti-anxiety effects, we decided to investigate the anxiolytic and sedative activity of hydroalcoho...
متن کاملAnxiolytic, Antidepressant and Anti-Inflammatory Activity of Methanol Extract of Leaves of Momordica Charantia Linn (Cucurbitaceae)
Methanol extract of dried leaves of Momordica charantia Linn ( Cucurbitaceae ) was investigated for anxiolytic, antidepressant and anti-inflammatory activities in animal models. Anxiolytic activity of methanol extract of dried leaves of Momordica charantia Linn was tested by elevated plus maze test and the results showed a significant anxiolytic effect comparable, with diazepam in all the t...
متن کاملاثرات ضداضطرابی و ضدافسردگی عصاره هیدروالکلی ریحان (Ocimum basilicum L.) در موشهای صحرایی مواجه شده با استرس مزمن بی حرکتی
Introduction: Studies show that chronic stress can lead to anxiety and depression. Basil (Ocimum basilicum L.) has antioxidant, anti-inflammatory, anti-apoptotic, anti-diabetic and anti-nociceptive properties. The aim of this study was to investigate the effect of basil hydro-alcoholic extract on chronic restraint stress-induced anxiety and depression in male Wistar rats. Methods: In this...
متن کامل